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    Mit Vorschusslorbeeren der Laienpresse wie "Fett-Weg-Pille"1 kommt das Roche-Produkt Orlistat (XENICAL) auf den Markt, ein Enzymhemmer gegen Übergewicht. Für ein weiteres Antiadipositum, das appetithemmende Antidepressivum Sibutramin (REDUCTIL), erwartet die BASF- Tochter Knoll demnächst die Zulassung. Beide Produkte sollen die Lücke füllen, die durch Marktrücknahme von Fenfluramin (PONDERAX) und Dexfenfluramin (ISOMERIDE) wegen lebensbedrohlicher Herzklappenschäden entstanden ist (a-t 12 [1997], 127). ORLISTAT (XENICAL): Die Idee, zum Abnehmen in die Verdauung einzugreifen, ist nicht neu. Schon 1982 wurden fälschlich als Lebensmittel bezeichnete alpha-Amylaseblocker (KALBLOCKER u.a.) vom Markt genommen. Der Nutzen blieb unbelegt (a-t 11 [1982], 100).2 Auch Acarbose (GLUCOBAY) ist ein Enzymhemmer. Dieser soll die Aufnahme von Glukose bremsen, wie bekannt, ohne relevanten Einfluss auf das Körpergewicht. Es hemmt gastrointestinale Lipasen und blockiert die Aufnahme von etwa 30% des zugeführten Fettes (a-t 9 [1997], 98).3,6 Im plazebokontrollierten klinischen Vergleich mit 688 Patienten unter hypokalorischer Diät haben diejenigen, die dreimal täglich 120 mg Orlistat einnehmen, nach einem Jahr 4 kg mehr abgenommen als Personen der Plazebogruppe (10 kg versus 6 kg). Wird Orlistat ein weiteres Jahr unter weniger strikter Diät eingenommen, steigt das Körpergewicht wieder um durchschnittlich 2 kg. Use of orlistat in obese, dyslipidemic patients metformin tablet Effects of Sibutramine Plus Orlistat in Obese Women Following 1. ORLISTAT XENICAL UND SIBUTRAMIN REDUCTIL - HILFE BEI.
     
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