It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. A patient will begin taking hydroxychloroquine for rheumatoid arthritisi Plaquenil hair changes Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. It is a known adverse reaction to quinine; hydroxychloroquine, as a synthetic derivative of this parent compound, may also put patients at risk of this complication. However, reports of hydroxychloroquine‐induced TTP are extremely rare in the literature. Drug-induced lupus should not be confused with drug side-effects, such as gastrointestinal, neurologic, or allergic symptoms that often occur after short-term therapy with various medications. These problems usually occur within a few hours or days of taking the medication. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Plaquenil induced rash Itching From Plaquenil DailyStrength, Suspected hydroxychloroquine‐induced thrombotic thrombocytopaenic. Chloroquine in early pregnancyDoses of plaquenilPlaquenil dental concerns Less common adverse effects of Plaquenil are drug-induced skin rashes. These rashes may consist of many small red bumps or bright red skin covering most of the body. The severity of the rash indicates to the clinician whether the drug needs to be stopped and even whether it will be tried again. Plaquenil Use in Autoimmune Diseases. Medications that can cause drug-induced lupus Lupus Foundation of America. Lichenoid Drug Eruption What You Should Know. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Aug 26, 2013 Yes. Hair bleaching, hair loss, skin pigmentation, rash and itching are recognized skin adverse reactions of plaquenil hydroxychloroquine. These reactions tend to be worse if a patient is taking other medications that have similar skin toxicity. Please consult a dermatologist to ensure skin lesions are not psoriatic because Plaquenil hydroxychloroquine use needs special precautions in. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative.