Pharmacokinetics of chloroquine phosphate

Discussion in 'Pharmacy Northwest Canada' started by Franny, 28-Feb-2020.

  1. walabyn Moderator

    Pharmacokinetics of chloroquine phosphate


    There is increased plasma protein binding, predominantly to α=8 hours) are prolonged by 50%. Systemic clearance is predominantly by hepatic biotransformation to more polar metabolites (quinine 80%, quinidine 65%) and the remaining drug is eliminated unchanged by the kidney.

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    How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length. Chloroquine phosphate is a 4-aminoquinolone that acts by inhibiting heme polymerase. 198 Chloroquine is well tolerated and in appropriate doses may be safely used by young children and pregnant women. 199 Transient nausea or vomiting is seen in a small proportion of individuals and may usually be reduced by taking the drug with food. The pharmacology of chloroquine and hydroxychloroquine is similar. The molecular weights of chloroquine and hydroxychloroquine are 320 and 336, respectively. Chloroquine and hydroxychloroquine are alkylated 4AQs that are water soluble, weak, amphiphilic bases that readily cross cell membranes.

    Quinine and chloroquine may cause potentially lethal hypotension if given by intravenous injection. Quinine is well absorbed by mouth or following intramuscular injection even in severe cases of malaria (estimated bioavailability more than 85%).

    Pharmacokinetics of chloroquine phosphate

    Aralen Chloroquine Uses, Dosage, Side Effects., Chloroquine - an overview ScienceDirect Topics

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  3. Medscape - Indication-specific dosing for Aralen, Chloroquine phosphate chloroquine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

    • Aralen, Chloroquine phosphate chloroquine dosing, indications..
    • Pharmacology of Chloroquine and Hydroxychloroquine..
    • Is Chloroquine a Cure for Coronavirus? Scientists Say..

    Hydroxychloroquine HCQ and chloroquine CQ are well absorbed 0.7-0.8 bioavailability when given orally. Severe malnutrition such as kwashiorkor effects absorption but diahrrea does not. Both HCQ and CQ have prolonged half-lives, between 40 and 50 days, and low blood clearance e.g. hydroxychloroquine's blood clearance is 96 ml/min. Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

     
  4. eddie123 Moderator

    To my shock and surprise I was diagnosed with Lupus on Wed. Does Plaquenil hydroxychloroquine cause weight loss ? I. How is plaquenil hydroxychloroquine used to treat lupus? Lupus and weight loss - Lupus - Inspire
     
  5. naka New Member

    Description: An exception occurred while processing your request. Hydroxychloroquine-Induced Retinal Toxicity - American. Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS Early Hydroxychloroquine OCT Abnormalities Preceding.
     
  6. mehtr0n User

    Hydroxychloroquine Plaquenil and Hair Loss Is my Plaquenil. Dec 12, 2019 Usually Plaquenil related hair loss starts 2-6 months after the Plaquenil was started. We call this a drug induced telogen effluvium. If the Plaquenil was started 10 years ago and a patient reports hair loss last month, it’s not very likely that the Plaquenil is the culprit.

    Plaquenil - FDA prescribing information, side effects and uses
     
  7. Plaquenil Hydroxychloroquine for Lupus - LupusCorner Starting Plaquenil. Plaquenil is sold in 200mg tablets. The recommended adult dosage for a person with lupus is 200 to 400 mg daily. It can be taken in two doses or at one time. Doses above 400 mg/day are not recommended. It is possible to overdose on Plaquenil as it is rapidly and completely ignored upon ingestion.

    Plaquenil hydroxychloroquine sulfate dosing, indications.