I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. It just seems like the fatigue is worse than it has ever been, and it doesn't seem to matter if I go to bed early or take a nap during the day. Woke up and cleaned the kitchen an hour later(my kitchen is a galley kitchen 8 ft maybe.no time) Took a nap. Early on I did get those stomach cramps and diarrhea. All my pain is tolerable and he sees no deformities so he says he doesn't see RA activity. Just because the pain is tolerable doesn't make me like it any better. He did a plaquenil test and sure enough it was low. Hydroxychloroquine and doxycycline Olistat and plaquenil Plaquenil confusion PLAQUENIL is indicated for the treatment of acute attacks and suppression of malaria. Warning In recent years, it has been found that certain strains of P. falciparum have become resistant to 4-aminoquinoline compounds including hydroxychloroquine as shown by the fact Plaquenil and Fatigue - from FDA reports Summary Fatigue is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. The effects of overdosage with hydroxychloroquine include headache, drowsiness, visual disturbances, convulsions, cardiovascular collapse, and respiratory arrest. Toxic retinopathy has also been associated with higher doses and longer duration of use. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed. I don't know if this is just the way RA is, or if it is a side effect of the medicine. Wasn't going to eat luch because I would have to move to do it.husband bought out. Kids came home, helped with homewrok, made dinner..picked up couch(because my blanket and pillow were there) Went to bed at 9. Drowsiness hydroxychloroquine Hydroxychloroquine - Side Effects, Dosage, Interactions., Will you have Fatigue with Plaquenil - eHealthMe Chloroquine absorptionCommon side effects of plaquenilHydroxychloroquine metabolism cypPlaquenil altitude sickness A 16-year-old girl presented to the emergency department ED with a blood pressure of 63 mm Hg by palpation, pulse of 110 beats/min, slurred speech, and drowsiness. History revealed she had taken a handful of her hydroxychloroquine 200 mg, levothyroxine, aspirin, and ibuprofen, 30 minutes before presentation. Treatment of hydroxychloroquine overdose - ScienceDirect. HCQ - Clinical Hydroxychloroquine, Serum. Hydroxychloroquine Side Effects - GoodRx. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. May 25, 2010 Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you.