Chloroquine function in lysosome

Discussion in 'Pharmacy Northwest Canada' started by soymnassofs, 28-Feb-2020.

  1. jimmyleee New Member

    Chloroquine function in lysosome

    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    The function of lysosomes is to remove waste as well as destroying a cell after it has died, called autolysis. A lysosome is an organelle containing digestive enzymes which it uses to function as the digestion and waste removal for cells, food particles, bacteria, etc. Jan 23, 2017 In addition to the well‐known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, ACE2. This may negatively affect the virus‐receptor binding and abrogate the infection. The unprotonated form of chloroquine preferentially accumulates in lysosomes as it rapidly diffuses across cell/organelle membranes. Once in the lower pH 4.6, environment of the lysosome chloroquine becomes protonated and can no longer freely diffuse out.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquine function in lysosome

    Chloroquine Oral Uses, Side Effects, Interactions., Targeting endosomal acidification by chloroquine analogs as a.

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  4. The aim of the present study was to examine in more detail the potential contribution of modification of lysosome function to the anti-inflammatory activities of the two drugs. Azithromycin and chloroquine both inhibit IL-6 and PGE 2 production, without affecting production of TNFα, in LPS-stimulated J774A.1 cells.

    • Impairment of lysosomal functions by azithromycin and..
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    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Oct 01, 2014 Fluorescent microscopic examination of intracellular zinc distribution demonstrated that free zinc ions are more concentrated in the lysosomes after addition of chloroquine, which is consistent with previous reports showing that chloroquine inhibits lysosome function. Inhibitory effect of chloroquine on bone resorp-. Key words chloroquine, lysosome, osteoclast, inflammatory bone disease. This study demonstrates the importance of the lysosome in the function as well as the differentiation of osteoclasts. Materials and methods 1Mice

  5. Pitch Well-Known Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Plaquenil Hydroxychloroquine - Side Effects, Dosage. Common Plaquenil side effects a study from FDA data. Methotrexate vs plaquenil side effects long term and short term
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