One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine blood stage Mylan hydroxychloroquine side effects Nov 10, 2019 American Academy of Ophthalmology AAO 2016 guidelines recommend to use HCQ at dosages ≤5 mg/kg real body weight to minimize toxicity. Important risk factors for retinal toxicity are daily and cumulative dosage of HCQ, duration of treatment, patient age and concomitant renal or liver diseases. Oral 200 to 400 mg daily as a single daily dose or in 2 divided doses. Note Due to the risk of retinal toxicity, do not exceed a daily dose of 5 mg/kg/day using actual body weight or 400 mg, whichever is lower AAO Marmor 2016; Melles 2014; Wallace 2019; Plaquenil labeling 2016. Jan 05, 2020 Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Aao plaquenil dosing Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at., Hydroxychloroquine Professional Patient Advice - Can chloroquine treat diarrheaPlaquenil pulmonary toxicity Braslow et al. examined rheumatologists’ adherence to the hydroxychloroquine HCQ dosing guidelines published by the American Academy of Ophthalmology in 2011 and revised in 2016. They performed a review of records at a single integrated health care entity NorthShore, Glenview, Ill. and found that about half of the patients on HCQ were prescribed higher doses than those recommended in the guidelines. Adherence to Hydroxychloroquine Dosing Guidelines by.. Hydroxychloroquine toxicity - EyeWiki. Hydroxychloroquine And Chloroquine Screening 2016 AAO.. The bottom line is that the daily dose should be 5.0 mg per kg or less, using real body weight,” said Michael F. Marmor, MD, at Stanford University in Palo Alto, Calif. This represents a significant change from the 2011 guidelines, which recommended using ideal body weight to determine dosages. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Therefore, the new guidelines suggest using a person’s height as a dosing factor. By the old standards, obese people, if dosed by their actual weight, could be overmedicated, Dr. Marmor said. If you’re short, the standard prescription of 200 mg of Plaquenil, twice daily, is too much, he said.