I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Chloroquine lyme Chloroquine dose in neonates Plaquenil and hair growth So that's the update. The lesson here is - for those who need to go off plaquenil, be careful about just going off it cold turkey. Obviously some of CAN do that, but if you don't know if you're one of them - better to be on the safe side and wean slowly. Take it from me! I am feeling much better after bumping my dose back up over the last few. I have been on plaquenil for 8 months and have lost 60 pounds from it this is a good thing also the fatigue is completely gone as is the morning stiffness. Plaq did not do enough to end my flare and get me off pred so doc convinced me to add MTX. She tried to take me off the plaq at my last appointment and I would NOT let her. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Coming off hydroxychloroquine RA and Hydroxychloroquine How Effective is it for., Plaquenil - Negative ana with plaquenilHydroxychloroquine surfactant deficiencyChloroquine lc3-iiPlaquenil oct scan Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This medicine is a off. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox. Plaquenil Withdrawal – Life As An Anomaly. My new rheumy, after running a trillion tests, has said that if it weren't for my previous rheumy's test results, he would say I did not have lupus. So, I asked about coming off of plaquenil. He said that I could stop plaquenil cold turkey. It slowly decreases effectiveness in the body. For patients taking hydroxychloroquine to prevent malaria Your doctor may want you to start taking this medicine 1 to 2 weeks before you travel to an area where there is a chance of getting malaria. This will help you to see how you react to the medicine. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects.