Swiss albino mice were administered with different amounts of CQ ranging from human therapeutic equivalent of 360 mg/kg body wt. We observed statistically significant generation of reactive oxygen species, liver toxicity, and oxidative stress. Our observation of alterations in biochemical parameters was strongly supported by real-time PCR measurement of m RNA expression of key biochemical enzymes involved in hepatic toxicity and oxidative stress. Concurrent administration of chloroquine Hydroxychloroquine risk of ophthalmology Hydroxychloroquine and blood pressure Some side effects of chloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Hepatitis, elevated liver enzymes, hepatotoxicity. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Ask your doctor about what chloroquine dose to take to treat rheumatoid arthritis, lupus, or sarcoidosis. Chloroquine Overdose. Symptoms of a chloroquine overdose may include Drowsiness; Dizziness We further tested quercetin, an antioxidant flavanoid, against CQ-induced hepatoxicity and found encouraging results as quercetin was able to drastically reduce the oxidative stress and hepatotoxicity resulting at higher dosages of CQ administration. However, the observed hepatotoxicity and accompanying oxidative stress following CQ administration show dose specific pattern with little or apparently no effect at therapeutic dose while having severe effects at higher dosages. Effect of chloroquine on liver enzymes Chloroquine Side Effects Common, Severe, Long Term -, Chloroquine - FDA prescribing information, side effects. Discontinuing plaquenilHydroxychloroquine skin discolorationHydroxychloroquine sulfate side effects Mar 25, 2002 The phenomenology of mefloquine's adverse effect profile, together with incidental details in some of the published case reports references to alcohol, and to known hepatotoxic co-medications such as the oral contraceptive pill suggest that for many mefloquine users adverse drug effects may be the result of primary hepatocellular injury, caused by the drug in association with one or more concurrent liver insults. Adverse effects of the antimalaria drug, mefloquine due to.. Chloroquine Aralen - Side Effects, Dosage, Interactions.. Plaquenil and elevated liver enzymes?. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. In the case of 100 mg kg −1 day −1 the effect was highly signiﬁcant compared with the other doses 10 and 30 mg kg −1 day −1. The results of the study revealed that α‐lipoic acid could offer protection against chloroquine‐induced hepatotoxicity. α‐Lipoic acid had a better protective effect when compared with silymarin, a.