Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Hydroxychloroquine sulfate wiki Chloroquine md anderson Crest plaquenil Some docs will start you out with a small burst of prednisone to calm things down while waiting for the Plaquenil to kick in. But with Sclero patients you have to be wary of using prednisone as it can cause scleroderma renal crisis. When linear scleroderma occurs on the face and forehead, it is called en coup de sabre. Systemic scleroderma is the most serious form of the disease, can affect the skin, muscles, joints, blood vessels, lungs, kidneys, heart and other organs. There are two major forms of systemic scleroderma limited cutaneous systemic sclerosis formerly. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Scleroderma Skin Involvement Itching Pruritus, Scleroderma Does plaquenil cause dizziness the longer you take itPlaquenil hairCalcium autophagy chloroquine Scleroderma is a rare condition, and patients with scleroderma need specialized care from a rheumatologist familiar with their condition. The care of patients with scleroderma requires a team approach. Many patients with scleroderma will input from different medical specialties including gastroenterology, pulmonary, cardiology, and others. Scleroderma and Systemic Sclerosis SSc An Overview.. Lupus and Scleroderma - Scleroderma News. Morphea - Diagnosis and treatment - Mayo Clinic. Scleroderma is a long-lasting autoimmune disease that affects your skin, connective tissue, and internal organs. Learn more about the types, causes, risk factors, symptoms, diagnosis, treatment. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously. eHealthMe has been monitoring drugs since 2008. See how 938 people just like you are living with scleroderma. Learn from their data and experience. Dismiss this notification PatientsLikeMe would like to remind you that your browser is out of date and many features of the website may not function as expected. Plaquenil Perceived effectiveness.