If so, how long does it take to make pain and stiffness go away? My dr is using it trying to get rid of all of my joint pain and stiffness that seems to be taking over my body. I had a pretty bad flare right after Christmas and my rheumy added methotrexate to what I was already taking. I don't know for sure if it is the plaquenil or other meds but my rheumy seems to have my inflammation/stiffness under pretty good control. Just rediced plaquenil from one tablet twice a day to one tablet once a day. I have noticed an improvement but it's very little. Chloroquine phosphate tablets bp 250 mg Sar of chloroquine With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Home remedies for joint pain and stiffness include taking a warm shower or bath, or applying a heating pad or ice pack. Apply ice if your joint is inflamed. Rest can also relieve these two common lupus symptoms. Avoid putting weight on the affected joint, or performing any activity that stresses it, and support it with a pillow or cushion. Track DMARD Effects. DMARDs are often standard treatment for rheumatoid arthritis. Even if you've been taking them a while, you still need to track how well they work and watch for side effects. He encouraged me to stay with it 3-4 months in order to get the full effect of any help I may receive. However, I think I may be getting migraines from it?! Just remember everyone has a different reaction to the various meds. I don't know if the plaq or MTX or prednisone is what's helping. Plaquenil takes quite a long time to get to its peak effectiveness: depending on what you read, anywhere from 3 months to a year. I also take Cimzia injections bi-weekly but that has only been for about 6 months. Although I do have to give credit to my rheumy because after just a month or two I wanted to be taken off the Cimzia as I didn't think it was really doing much. Hi brandi, I tried Plaquenil, unfortunately for me the side effects is what took me off of it. The kind where I wanted to scratch every inch of my skin off. Took about a week of taking 2 kinds of allergy meds before I got rid of that effect. I have 2 days a week, after my MTX, where I'm just sick. I've been on the MTX now for about a month and when I see my rheumy in 2 weeks I'm going to see if I can try something else or stop taking it. Plaquenil and muscle stiffness Will you have Muscle aches with Plaquenil - eHealthMe, Coping with Common Lupus Symptoms and Treatments Chloroquine and nitrifying bacteriaWhat happens when you take plaquenil with out having lupusGeneric plaquenil cost I looked back through my lab work. Even while taking 400mg of Plaquenil and 15mg of Prednisone also an immunosuppressant, my immune system was still overactive. My Absolute Neutrophils good indicator of immune system function didn't get suppressed to a NORMAL range until I increased the Plaquenil to 600mg/day while still taking the Prednisone. Do either hydroxychol/Plaquenil put you at risk for greater.. Track DMARD Effects - WebMD. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Muscle weakness also may be a side effect of certain drugs used to treat lupus and related conditions, including prednisone and other corticosteroids, cholesterol-lowering drugs and hydroxychloroquine Plaquenil®. Therefore, drug-induced muscle disease should be ruled out as a cause of weakness if you are taking any of these medications, as drug-induced muscle weakness usually does not produce elevated levels of muscle enzymes as is seen in lupus myositis. I agree with CameronC and all others who are "pro" Plaquenil. I was diagnosed with Limited Systemic Scleroderma in late 2001 & started Plaquenil at the beginning of 2002. Joint and muscle pain and overwhelming fatigue were my worst symptoms. Jul 10, 2012 The swelling and stiffness in my joints is the only thing Plaquenil helped for me. It did not help with pain, fatigue, or any other symptoms, but it definitely reduced the stiffness in my small joints like my fingers, which used to be swollen and stiff every morning for about an hour.