It seems to me the cure is worse then the condition! Hi im starting plaquenil 200mg twice a day was wondering how far apart should the dose, be and best times to take it ,what are some of the side effects anyone has had and how long did it take to start working thank u You take plaquenil twice a day, approximately 12 hours apart. Icd 10 coding for plaquenil use Chloroquine mechanism of action lupus Of all the drugs I've had to take for lupus, plaquenil is probably the most mellow. It is my understanding that if it affects your eyes, it's a slow onset type thing, so if you're having your eyes checked regularly every 6mos, you will be fine. I understand these may go away. Is there anything I can do to reduce these symptoms? I always take the Plaquenil with a meal. Answer. You might try starting at 1/2 a tablet and work your way up slowly. Also, generic plaquenil hydroxychloroquine is often associated with more GI side effets than the name brand. WebMD provides information about which foods to avoid while taking Plaquenil Oral. You can take it with food if it upsets your stomach. The most common side effect is mild nausea and occasional stomach cramps. Best way to take plaquenil Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?, Stomach problems with Plaquenil • Johns Hopkins Arthritis Center Hydroxychloroquine rxlistHydroxychloroquine hair lossAdvantages of chloroquineHydroxychloroquine 200 mg dailyHair loss and plaquenil May 25, 2009 You are supposed to take it after food Barb. It stands to reason that if it comes out as fast as it went in it won't get absorbed as well as it might. I had trouble with diarrhoea when I first started to take Plaquenil and that was even after food, but it wore off after several weeks. I always take it after food and have no problems now. Best way to take Plaquenil? Lupus Forums at The Lupus Site. Foods to Avoid When Taking Plaquenil Oral. How Do Ophthalmologists Look for Plaquenil Damage? - American.. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Although there are few drug interactions with hydroxychloroquine, to be safe be sure to tell your doctor about all of the medications you are taking, including over-the-counter drugs and natural remedies. Be sure to notify your other physicians when taking this drug.