Acute chloroquine poisoning

Discussion in 'Generic Chloroquine' started by Palpatine, 04-Mar-2020.

  1. Andromino Guest

    Acute chloroquine poisoning


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    EUROPEAN JOURNAL OF PHARMACOLOGY 25 1974 210-215. NORTH-HOLLAND PUBLISHING COMPANY EFFECT OF HYPERTHERMIA ON ACUTE CHLOROQUINE TOXICITY IN RABBITS E. AYITEY-SMITH, G. L. BOYE, N. NICHANI and R. A. LEWIS Department of Pharmacology, University of Ghana Medical School, P. O. B. 4236, Accra, Ghana Received 3 July 1973 Accepted 22 October 1973 E. AYITEY-SMITH, G. L. BOYE, N. NICHANI and R. A. LEWIS. Apr 02, 2019 Consider a 1 mmol/kg bolus of NaHCO3 prior to intubation to guard against acidemia from hypoventilation, which may worsen chloroquine toxicity. Some studies suggest that the use of thiopentone for induction is associated with cardiac arrest in cases of severe chloroquine toxicity. Jul 30, 2019 The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Acute chloroquine poisoning

    Chloroquine and Hydroxychloroquine Toxicity Practice., Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum

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  7. Chloroquine causes rare but life-threatening toxicity. The prognostic value of plasma chloroquine concentrations in acute poisonings remains poorly investigated. We investigated the hypothesis that blood chloroquine concentrations better predicted chloroquine poisoning severity than plasma concentrations.

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    Quinine and chloroquine poisoning are characterized by severe cardiovascular toxicity resulting from sodium and potassium channel blockade, leading to hypotension, shock, arrhythmias and cardiac arrest. Quinine poisoning can cause irreversible visual loss. Severity of symptoms is closely related to the ingested dose and plasma concentration. Single-dose activated charcoal can be given within 1. The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia. Of chloroquine is excreted unchanged; Resuscitation Coma Prompt intubation and ventilation, if acidaemia exists, give sodium bicarbonate 1 – 2 mmol/Kg IV to prevent further toxicity during intubation. End goals should be a narrow QRS 100ms and a pH 7.45

     
  8. Sysfaray Guest

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    Common use Aralen is an aminoquinoline which used to treat or prevent malaria infections and a certain type of parasitic infection. Chloroquine - FDA prescribing information, side effects and uses CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria Aralen Buy - SSFDrugstore
     
  10. sandik XenForo Moderator

    Hydroxychloroquine - Wikipedia Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during

    Hydroxychloroquine and lupus pregnancy review of a series of.