Please review the following URL and make sure that it is spelled correctly. The administration of chloroquine or hydroxychloroquine to albino and pigmented (hooded) rats at a daily dosage of 40 mg/kg produces a rapid rise in tissue concentrations of the drugs during the first month of medication, but comparatively little further rise when the medications are continued for two additional months. Chloroquine treatment method Plaquenil cessation In order to determine the pharmacokinetic disposition of chloroquine CQ and its active metabolite, desethylchloroquine DECQ, when administered as intermittent presumptive treatment in pregnancy IPTp for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were administered three daily doses of 450 mg CQ 8.5 mg/kg of body. TOXICOLOGY AND APPLIED PHARMACOLOGY 7, 627-636 1965 Metabolism of Chloroquine and Hydroxychloroquine in Albino and Pigmented Rats' EVAN W. MCCHESNEY, WILLIAM F. BANKS, JR. AND DAVID J. SULLIVAN" Sections of Biochemistry and Pathology, Sterling-Winthrop Research Institute, Rensselaer, New York 12144 Received July 10, 1964 Chloroquine3 CQ was first prepared in this country in quantity 20. IN VITRO METABOLISM OF CHLOROQUINE IDENTIFICATION OF CYP2C8, CYP3A4, AND CYP2D6 AS THE MAIN ISOFORMS CATALYZING N-DESETHYLCHLOROQUINE FORMATION. Denis Projean, Bruno Baune, Robert Farinotti, Jean-Pierre Flinois, Philippe Beaune, Anne-Marie Taburet and Julie Ducharme. However, rats degrade the latter compound more extensively, so that their total mean tissue content of 4-aminoquinoline bases is greater than 30 mg/kg at that time. The mean tissue concentration of chloroquine at 1 month is about 100 mg/kg, compared to about 30 mg/kg for hydroxychloroquine. Metabolism of chloroquine CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG, Metabolism of chloroquine and hydroxychloroquine in albino. Chloroquin vs quinineChloroquine storage conditionsPlaquenil mechanism of action Chloroquine undergoes appreciable degradation in the body. The main metabolite is desethylChloroquine, which accounts for one fourth of the total material appearing in the urine;bisdesethylChloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts. Chloroquine - FDA prescribing information, side effects and uses. IN VITRO METABOLISM OF CHLOROQUINE IDENTIFICATION OF.. Clinical Pharmacokinetics and Metabolism of Chloroquine.. Chloroquine has a high affinity for tissues of the parasite and is concentrated in its cytoplasm. As a weak base, it increases the pH of the intracellular lysosome and endosome. A more acidic medium in these organelles is needed for the parasite to affect mammalian cells. As a result, chloroquine inhibits growth and development of parasites. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Both chloroquine and hydroxychloroquine are substrates for cytochrome P450 CYP enzymes enzymes responsible for the metabolism of multiple drugs and hence can interfere with other drugs 38,46,47.