Even then we often have our symptoms treated long before they feel confident in making a Lupus diagnosis. all lupus type blood testing has came back negative as well two skin biopsies. People often have some intestinal issues when first starting plaquenil - things generally settle down in a few days. Also, it's good to have at least a few bites of food with it. It takes a rheumotologist to completely diagnose and treat Lupus. Plaquenil blood pressure Plaquenil bone marrow Chloroquine autophagy off target Yes, plaquenil is difficult to adjust first, but after the first year of treatment and side effects, the benefits outweigh the problems. So, stick with it. In my opinion, the plaque nil is keeping the immune system regulated and the pain and other symptoms described will reduce. Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. I have been taking plaquenil for a little over 10 years and getting eye exams regularly. Suddenly I'm experiencing eye problems blilnd spots. I have stopped taking plaquenil, but now I'm being told by doctors that the damage is not necessarily reversible especially if you have taken it for a long time. Or, like Lynnwood said, a doctor may try us on a medication to see if our response to it is diagnostically useful. I have sun induced rashes and painful hip joints and burning in the very low back area. Also, is intestinal distress a side effect of plaquenil?? What can plaquenil do to you if taken wrong Can ANA go away & Lupus Stay? - Lupus - MedHelp, Skin Discoloration and Plaquenil - Arthritis Information Does plaquenil interact with alcoholPlaquenil or methotrexate Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower. Prednisone and Plaquenil question" Lupus Community.. Has anyone experienced plaquenil toxicity with damage to eyes?. Don't want to take plaquenil anymore - HealthBoards. Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug. Hello friends, I take my Plaquenil in the morning with breakfast. I feel very shaky, dizzy and just off all day. Does anyone take it at night? Will it keep me up? Why do I have to take it in the morning.