Hydroxychloroquine in lupus nephritis

Discussion in 'Chloroquine' started by iven, 04-Mar-2020.

  1. a_polli Well-Known Member

    Hydroxychloroquine in lupus nephritis


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. -Each dose should be taken with a meal or a glass of milk.

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    In a study of membranous lupus nephritis, 38 patients were treated with corticosteroids and azathioprine; after 12 months of treatment, 67% of patients had a complete remission and 22% had a partial remission, with only 11% resistant to treatment. Long-term follow-up of 12 years showed 19 episodes of renal flares. In 1956, the U. S. Food and Drug Administration approved HCQ for symptoms of lupus and rheumatoid arthritis, particularly skin inflammation, hair loss, mouth sores, fatigue, and joint pain. Dosing. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Lupus Nephritis. Inflammation of the nephrons, the structures within the kidneys that filter the blood, is called glomerulonephritis, or nephritis. Lupus nephritis is the term used when lupus causes inflammation in your kidneys, making them unable to properly remove waste from your blood or control the amount of fluids in your body.

    -Concomitant therapy with an 8-aminoquinoline drug is necessary for the radical cure of vivax and malariae malaria. Use: Malaria prophylaxis Acute attack: 800 mg (620 mg base) orally followed in 6 to 8 hours by 400 mg (310 mg base), then 400 mg (310 mg base) once a day for 2 consecutive days; alternatively, a single dose of 800 mg (620 mg base) has also been effective Alternate dosing based on body weight: A total dose representing 25 mg/kg is administered in 3 days, as follows: First dose: 10 mg base/kg (not to exceed 620 mg base) orally Second dose: 5 mg base/kg (not to exceed 310 mg base) orally 6 hours after first dose Third dose: 5 mg base/kg orally 18 hours after second dose Fourth dose: 5 mg base/kg orally 24 hours after third dose Comments: -Each dose should be taken with a meal or a glass of milk.

    Hydroxychloroquine in lupus nephritis

    Lupus and Kidney Disease Lupus Nephritis NIDDK, Drug spotlight on hydroxychloroquine Lupus Foundation of.

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  6. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives.

    • Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center.
    • Plaquenil side effects - kidney problems? - Life With Lupus.
    • Prednisone and Plaquenil drug interaction Lupus nephritis..

    Hydroxychloroquine use is associated with lower odds of persistently positive antiphospholipid antibodies and/or lupus anticoagulant in systemic lupus erythematosus. J Rheumatol. J Rheumatol. 2013 ;401 30 – 33. In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis. Our results provide evidence that hydroxychloroquine has a benefit for renal remission when MMF is used as the initial therapy for MLN. Although hydroxychloroquine is frequently stopped in patients with lupus nephritis, this study suggests it should be started or maintained.

     
  7. neyouryour Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term - Perioperative management of the. - PubMed Central PMC Hydroxychloroquine Plaquenil
     
  8. nevalex New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Indications, Side Effects, Warnings - Chloroquine Aralen - Side Effects, Dosage, Interactions. Pharmacology of Chloroquine and Hydroxychloroquine.
     
  9. vladway Guest

    Does Plaquenil make you tired? DailyStrength Mel1967 11/03/2009. Hi Phoebe, I have been on plaquenil for many years and have not experienced a sudden onset of fatigue after taking it. While those of us with lupus never truly find anything to relieve fatigue, plaquenil is suppose to help with fatigue rather than create more from what I understand.

    Plaquenil Side Effects Common, Severe, Long Term -
     
  10. Syrius XenForo Moderator

    Fundus Autofluorescence in Hydroxychloroquine Toxicity. Fundus Autofluorescence Is Not the Best Early Screen for Hydroxychloroquine Toxicity—Reply Ian R. Gorovoy, MD; Mark S. Gorovoy, MD Fundus autofluorescence images of the left eye of a 59-year-old women with sarcoidosis who received 200 mg of hydroxychloroquine sulfate twice daily for 15 years.

    Plaquenil Toxicity Screening - Retina Group of New York