B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Skin cancer side effect of plaquenil Map of chloroquine resistant malaria Cutaneous pigmented lesions were found in 21 cases 51%, mucous pigmentation in 5 cases 12% and nail pigmentation in 1 case 2.5%. In 12 of 41 29% of the hydroxychloroquine users, we conclude a hydroxychloroquine-induced pigmentation. Hydroxychloroquine induced cutaneous pigmentation. cular hemosiderin on special staining. 3 Cutaneous hyperpigmentation has been suggested as a marker. 4 Millard TP, Kirk A, Ratnavel R. Cutaneous hyperpigmentation during therapy with hydroxychloroquine. Clin Exp Dermatol 2004;–3. 5 Dwyer CM, Cuddihy AM, Kerr RE, et al. Skin. Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Cutaneous hyperpigmentation during therapy with hydroxychloroquine Skin Pigmentation with Hydroxychloroquine Plaquenil., Hydroxychloroquine induced cutaneous pigmentation a. Hydroxychloroquine and nerve damage Cutaneous hyperpigmentation during therapy with hydroxychloroquine. J Clin Rheumatol 2007; 13 113. Rood MJ, Vermeer MH, Huizinga TW. Hyperpigmentation of the skin due to hydroxychloroquine. Scand J Rheumatol 2008; 37 158. Reynaert S, Setterfield J, Black MM. Hydroxychloroquine-induced pigmentation in two patients with systemic lupus. Hyperpigmented Forearms and Nail A Quiz HTML Acta.. Hydroxychloroquine-Induced Hyperpigmentation JCR Journal.. Adverse cutaneous reactions to hydroxychloroquine are more.. Background Antimalarials including hydroxychloroquine HCQ have been used in the treatment of systemic lupus erythematosus SLE for more than 50 years. Few cases of hyperpigmentation attributed to HCQ have been reported in the literature from different geographical areas. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9.