Chloroquine maculopathy

Discussion in 'Chloroquine Without A Doctor Prescription' started by misWEB, 19-Mar-2020.

  1. Reez User

    Chloroquine maculopathy


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Hydroxychloroquine is used widely for the treatment of systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatologic conditions. Findings on eye examination include the following Corneal deposits. Posterior subcapsular lens opacity chloroquine. Irregularity in the macular pigmentation and blunting of the foveal reflex early. Bull’s eye maculopathy classic finding in non-Asian patients. Peripheral pigment. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Chloroquine maculopathy

    Hydroxychloroquine Side Effects, Dosage, Uses, and More, Chloroquine and Hydroxychloroquine Toxicity Practice.

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  4. Chloroquine Retinopathy Rheumatic Disease. Alastair K. Denniston. Ocular complications of rheumatological therapies may relate. Autofluorescence Imaging. Monika Fleckenstein. FAF imaging may show distinct alterations due. MEDICAL RETINA. Age-related macular degeneration AMD is a.

    • Chloroquine Retinopathy - an overview ScienceDirect Topics.
    • Chloroquine - FDA prescribing information, side effects..
    • Bull's-eye maculopathy due to hydroxychloroquine toxicity.

    Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.

     
  5. serx XenForo Moderator

    We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. Inhibition of autophagy with chloroquine is effective in. What is the best applicable inhibitor of autophagy? Autophagy blockade and lysosomal membrane permeabilization.
     
  6. Vitkor945 XenForo Moderator

    Revised Recommendations on Screening for Chloroquine and. Background. The American Academy of Ophthalmology recommendations for screening of chloroquine CQ and hydroxychloroquine HCQ retinopathy were published in 2002, but improved screening tools and new knowledge about the prevalence of toxicity have appeared in the ensuing years.

    New Screening Guidelines for Hydroxychloroquine Toxicity