Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil equivalent Chloroquine headache Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. This review will evaluate current methods to directly and indirectly modulate autophagy to prevent cancer and to overcome resistance to anticancer therapy. PubMed was searched for keywords autophagy, hydroxychloroquine, chloroquine, and cell death for preclinical and clinical studies evaluating autophagy-modulating pathways and compounds. Chloroquine CQ is a 4-aminoquinoline drug used for the treatment of diverse diseases. It inhibits lysosomal acidification and therefore prevents autophagy by blocking autophagosome fusion and degradation. In cancer treatment, CQ is often used in combination. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine autophagy off target PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine., Autophagy modulation a target for cancer treatment. Plaquenil side effects blood pressureHydroxychloroquine elevated serum porphyrinWould hydroxychloroquine cause a positive opioid drug testWhat stage of infection did the chloroquine treatPlaquenil and inflammation The protective action seen with chloroquine may be in part due to off-target effects on apoptosis separate from blocking lysosomal activity in autophagy. We conclude pharmacologic induction of autophagy RESEARCH Open Access Rapamycin up-regulation of autophagy.. Chloroquine sensitizes breast cancer cells to chemotherapy.. Oncotarget Chemical modulation of autophagy as an adjunct.. Autophagy1 is a complex of adaptive cellular response that enhances cancer cell survival in the face of cellular stresses such as chemothery. Here we show that in human gallbladder carcinoma GBC cells lines, SGC-996 and GBC-SD, autophagy is induced by the DNA damaging agent 5-fluorouracil 5-FU. While in combination with the pre-treatment of chloroquine CQ, a inhibitor of autophagy, the. Inhibiting autophagy with chloroquine sensitises EGFR M+ cells to combined treatment with EGFR and AKT inhibitors. In order to determine whether AKT inhibitor-induced autophagy is acting as a pro- or anti-survival mechanism in NSCLC cells, we indirectly blocked autophagy with a pharmacologic inhibitor chloroquine, which disturbs lysosome function. Such studies are the basis for most of the current efforts to target autophagy in. this may only apply in tumor cells that start off being dependent on autophagy. J. Thorburn, F. Gidan, L. Staskiewicz, S. Morgan, C. Cummings, P. Maycotte, A. ThorburnRegulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is.