The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Hydroxychloroquine causing rash where Coming off plaquenil View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more. Hydroxychloroquine Remove Hydroxychloroquine from your drug comparison Methotrexate Remove Methotrexate from your drug comparison Celebrex celecoxib Remove Celebrex from your drug comparison Add to compare Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Methotrexate is once a week usually and most of the side effects would hit the next day so some people choose to take it on a Friday or Saturday night and sleep through any potential side effects some people report that caffeine may lower the efficacy of methotrexate, though results have been inconclusive. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Methotrexate vs hydroxychloroquine Methotrexate vs. Plaquenil - Autoimmune diseases - Inspire, Compare Plaquenil vs Methotrexate - Chloroquine phosphate ebayDoes hydroxychloroquine help with fatigueGeneric plaquenil gg320Plaquenil rob holland Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Which would you pick and why? - Plaquenil or Methotrexate. Plaquenil vs Methotrexate rheumatoid - reddit. What Is the Difference between Hydroxychloroquine and.. Methotrexate for Your RA. Methotrexate is one of the most effective medications to treat rheumatoid arthritis RA. It's the first drug most doctors prescribe after you’re diagnosed. It will. What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx.