Affecting my self esteem Your definitely not alone. I’m fair hair n skin but I’m getting brown blotches. I am not looking to when it starts coming down my face hope I can b helped in time. Effects of plaquenil in pregnancy Chloroquine injection route 400 mg plaquenil at night Side effects of plaquenil and methotrexate She mentioned that Plaquenil can cause brown blotchy spots on skin. I've been on Plaquenil 4 months and I have noticed some brown spots on my face. I had no idea what they were and was going to see a Dermatologist. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. My scalp has turned black and my forehead side of face r slowly turning ears r totally black shiny plate .various long and boring treatments from docs but to no avail.finally I have been asked to stopped taking h for lupus for 3 next step will b decided. I am surprised to hear about this cos my rheumy said hydroxy helps to lighten the skin. One of them is on my nose and people keep telling me I’ve a dirt mark. I'm from Indian sub continent and am a "woman of colour like urself" approx 2 years ago had sudden deep painful itch in scalp and body. Yes I have been on this med since 2003 and I have black patches all over. Plaquenil dark spots Lupus Medicines Hydroxychloroquine - Brigham and Women's., Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Can you take prednisone with hydroxychloroquinePlaquenil compared to quinine Call your doctor right away if you lose part of your eyesight, if you see dark spots, or if you see only part of an object. Have an eye exam as you have been told by your doctor. Have your blood work checked if you are on Plaquenil hydroxychloroquine for a long time. Talk with your doctor. Plaquenil Indications, Side Effects, Warnings -. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil and skin discoloration - Sjogren's World. I have been on Plaquenil for two years for RA, for which it has been great apart from a bit of itchiness, which I've mentioned elsewhere on this site in reply to another member asking about this. But lately the skin on my arms looks a bit blotchy. By this I mean that there are numerous small whiter-coloured circles whiter than the surrounding skin, anyway, almost like scars, or rather like. Each white-to-off-white, film-coated, peanut-shaped tablet with "PLAQUENIL" in black on one side contains 200 mg of hydroxychloroquine sulfate equivalent to 155 mg of base. Nonmedicinal ingredients black ink, calcium hydrogenophosphate, carnauba wax, corn starch, magnesium stearate, opadry White YS-I-7443, and polyethylene glycol 400. Plaquenil can change the pigmentation in the skin, so it would stand to reason that it can do the same with hair. I have experienced the change in pigmentation on my legs. It looks like I have a huge bruise on the back of my leg which extends from the calf to the ankle. I call it a perma-bruise.