Chloroquine weak base

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    Chloroquine weak base


    Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

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    By nature, chloroquine is a diprotic weak base and, at physiological pH, can be found in unprotonated CQ, mono-protonated CQ + and di-protonated CQ ++ forms. According to the weak base model, CQ is the only form permeable in the membrane and able to diffuse into the erythrocyte up to DV. Chloroquine is a weak base which can partition into acidic vesicles such as endosomes and lysosomes, resulting in inhibition of endosomal acidification and lysosomal enzyme activity. Because acidic pH of endosomes is a prerequisite of endosomal TLR activation, chloroquine can serve as an antagonist for endosomal TLRs. Jul 08, 2019 Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

    Chloroquine weak base

    Hydroxychloroquine Uses, Dosage & Side Effects -, Chloroquine Inhibitor - Novus Biologicals

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  4. Because chloroquine is a weak base, it increases vesicle pH by that mechanism in chloroquine-susceptible and resistant parasites and mammalian cells based on its two pKs and on the delta pH between the acid vesicle and the extracellular environment.

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    The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. Prophylaxis against Chloroquine-sensitive Plasmodium species Hydroxychloroquine has similar pharmacokinetics to chloroquine, with rapid gastrointestinal absorption and elimination by the kidneys. Cytochrome P450 enzymes CYP2D6, 2C8, 3A4 and 3A5 metabolize hydroxychloroquine to N-desethylhydroxychloroquine. Pharmacodynamics. Antimalarials are lipophilic weak bases and easily pass plasma membranes. Oct 01, 2018 The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. Prophylaxis against Chloroquine-sensitive Plasmodium species

     
  5. AMURSUIMI Moderator

    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Chloroquine - Wikipedia Chloroquine C18H26ClN3 - PubChem Chloroquine - SlideShare
     
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