Plaquenil retinopathy pathogenesis

Discussion in 'Canadian Pharmacy' started by Foxter, 26-Feb-2020.

  1. JULIASOCHI XenForo Moderator

    Plaquenil retinopathy pathogenesis


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    The most important predictors of hydroxychloroquine retinopathy are thought to be high-dose and long-term 5 years use, but current evidence is limited to retrospective studies, most of which. DR can be divided into 2 stages non-proliferative diabetic retinopathy NPDR and proliferative diabetic retinopathy PDR. NPDR can be further divided into mild, moderate, and severe stages. 1 In general, retinopathy advances from mild nonproliferative abnormalities, characterized by increased numbers of microaneurysms. Plaquenil or hydroxychloroquine is under the quinolone family. These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Plaquenil retinopathy pathogenesis

    Diabetic retinopathy Pathogenesis - UpToDate, Pathophysiology – Diabetic Retinopathy

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  6. Diabetic retinopathy involves anatomic changes in retinal vessels and neuroglia. The pathogenetic mechanism responsible for retinopathy is imperfectly understood, but much of the mechanism is apparently reproduced by experimental diabetes in animals and by chronic elevation of blood galactose in nondiabetic animals. The evidence that retinopathy is a consequence of excessive blood sugars and.

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    Blood flow studies have shown that in diabetes the retinal blood flow increases markedly with progress of background retinopathy, decreasing finally where proliferative retinopathy, with marked arteriolar narrowing, is present. On the basis of these findings a working hypothesis for the pathogenesis of diabetic retinopathy is presented. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during Mar 17, 2019 Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye.

     
  7. Jim Smit XenForo Moderator

    Please welcome our newest member, Angel Whisperer.326 Guest(s), 7 Registered Member(s) are currently online. Foods and Medications to Avoid If You Have Lupus Johns. Can Plaquenil be taken with antibiotics? - Page 3 Plaquenil hydroxychloroquine sulfate Drug / Medicine.
     
  8. Vara XenForo Moderator

    Optical coherence tomography is a well-established diagnostic imaging technique that allows both qualitative (morphology and reflectivity) and quantitative (thickness, mapping and volume) analyses of the retinal architecture. PLAQUENIL - PLM Hydroxychloroquine Plaquenil Toxicity and. Hydroxychloroquine-induced retinal toxicity medicine
     
  9. Spartakus Moderator

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  10. SEO_noob Well-Known Member

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Plaquenil belongs in a class of medications known as disease-modifying.

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