Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and lupus anticoagulant Accidental double dose of plaquenil Can you take meloxicam with plaquenil Plaquenil can cause loss of appetite and I agree that losing weight at this rate and suffering diarrhea is not healthy and might mean you become ill nourished and dehydrated. I suggest lowering the dose, going back to the original, until your tum has settled down then very gradually increasing it to give your body the maximum chance to adjust to the higher dose. The linear regression analysis revealed that the duration of treatment was significantly associated with a decrease in Bacteroidetes P = 0.0001, Firmicutes P = 0.002, and total bacteria P 0.00001. Abnormal weight gain is a side effect of long-term doxycycline and hydroxychloroquine treatment. Based on this information, possible bothersome but usually not dangerous side effects of Plaquenil may include Nausea and vomiting. Diarrhea and abdominal pain. Headaches. Dizziness or a spinning sensation vertigo. Ringing in the ears tinnitus. Loss of appetite. Nightmares. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects weight loss Hair loss and Plaquenil? DailyStrength, Abnormal Weight Gain and Gut Microbiota Modifications Are. Keflex and plaquenil Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Plaquenil Side Effects - Antibiotics Home Page. Common and Rare Side Effects for Plaquenil Oral. Check with your doctor immediately if any of the following side effects occur Incidence not known. Blistering, peeling, loosening of the skin blurred vision or other vision changes chest discomfort, pain, or tightness cough or hoarseness dark urine decreased urination defective color vision diarrhea difficulty breathing The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given. Common side effects Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. Dizziness Precautions with this side effect Do not drive, use machinery. Cramps. Headache. Dry skin. Loss of appetite.