Chloroquine inhibits autophagy in mice

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  1. Galiana XenForo Moderator

    Chloroquine inhibits autophagy in mice


    Phone: (215) 746-5515; Fax: (215) 746-5511; E-mail: [email protected] in: JCI | Pub Med | Google Scholar Cancer Research Institute, University of California San Francisco Comprehensive Cancer Center, San Francisco, California, USA. Thompson, Department of Cancer Biology, Abramson Family Cancer Research Institute, 421 Curie Boulevard, 450 BRB II/III, Philadelphia, Pennsylvania 19104, USA. Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1].

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    Aug 26, 2018 Chloroquine CQ, a known autophagy inhibitor, disrupts lysosomal function by increasing lysosomal pH, thereby causing acidification, which, in turn, inhibits autophagy. The lung cancer cells were pretreated with CQ to determine whether AZD9291 induced an autophagic flux. Degradation. Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial for the outcome of numerous specific diseases. Several lysosomal inhibitors such as bafilo-mycin A 1 BafA 1, protease inhibitors and chloroquine CQ, have been used interchangeably to block Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious

    This accumulation leads to inhibition of lysosomal enzymes that require an acidic p H, and prevents fusion of endosomes and lysosomes. TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN- Production. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes.

    Chloroquine inhibits autophagy in mice

    Chloroquine Inhibits Autophagy to Potentiate Antiestrogen., Chloroquine inhibits autophagic flux by decreasing autophagosome.

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  7. Chloroquine inhibits autophagy by blocking acidification of the lysosome, preventing fusion with the autophagosome. In a stressed cell, dependent on autophagy, this last step when blocked results in increased generation of autophagosomes, eventually undergoing either apoptotic or necrotic cell death.

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    Moreover, small molecule inhibitors targeting the autophagy pathway are not likely to be capable of irreversible, complete target inhibition, as is the case of genetic deletion of an ATG. Second, human cancer cell lines can be unaffected by autophagy suppression e.g. Maycotte et al. 2014; Mandelbaum et al. 2015. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. We show that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle. which might contribute to the fusion impairment. Strikingly, HCQ-treated mice. Chloroquine CQ, a known autophagy inhibitor, disrupts lysosomal function by increasing lysosomal pH, thereby causing acidification, which, in turn, inhibits autophagy. The lung cancer cells were pretreated with CQ to determine whether AZD9291 induced an autophagic flux.

     
  8. irinemeliora Well-Known Member

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  9. shako Moderator

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  10. Postal23 New Member

    Hydroxychloroquine toxicity - EyeWiki Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1

    Hydroxychloroquine MedlinePlus Drug Information