Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil success rheumatoid arthritis Maculopathy plaquenil Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. Nov 15, 2015 Indeed, Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. This is why Chloroquine has become part of many clinical trials, in combination with chemotherapy and other form of cancer treatments. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine autophagy Chloroquine, an autophagy inhibitor, potentiates the., Chloroquine for research Cell-culture tested InvivoGen Nifedipine and hydroxy chloroquinePlaquenil and osteoporosis Chloroquine phosphate is in a class of drugs called antimalarials and amebicides. It is used to prevent and treat malaria. It is also used to treat amebiasis. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Chloroquine MedlinePlus Drug Information. Chloroquine & Hydroxychloroquine supporting chemo.. Chloroquine C18H26ClN3 - PubChem. Oct 01, 2018 Chloroquine phosphate tablets, Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater. Chloroquine phosphate tablets are an antimalarial and amebicidal drug. To enable autophagy studies, we offer specific tools to report LC3B and p62 localization. Labeling of p62 serves as a useful marker for the induction of autophagy, clearance of protein aggregates, and the inhibition of autophagy. Labeling of LC3B serve to track the binding of p62 and subsequent recruitment of autophagosomes. Premo Autophagy Sensor Tandem LC3B can be used to discriminate. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy. The use of chloroquine in combination with other chemotherapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, and inhibition of autophagy by chloroquine may sensitize not only cancer cells, but also normal organs to chemotherapy.