Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Rash with plaquenil Hydroxychloroquine sulfate tablets Plaquenil rash photos The most common place for Hydroxychloroquine to cause a problem is in a ring of the macula surrounding the fovea which is demonstated in the visual field test you can see in the picture above. The black areas are the areas the patinet couldn't see well. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as. Inability to move the eyes; increased blinking or spasms of the eyelid; joint or muscle pain; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs; loss of hearing; lower back or side pain; noisy breathing; painful or difficult urination; red irritated eyes; red skin lesions, often with a purple center While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Eye problems caused by plaquenil Rx Side Effects New Plaquenil Guidelines and More., The Risk of Retinal Toxicity with Plaquenil Hydroxychloroquine less common side effectsDiscontinuing plaquenil Plaquenil can cause retinal damage which can be reversed if caught early. The damage to your eye would start with your peripheral vision which is why a thorough opthamalic exam and visual field. Plaquenil and vision" Lupus Community - Support Group. Hydroxychloroquine Side Effects Common, Severe, Long Term.. New Plaquenil Guidelines. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, Some of the medications used to treat rheumatoid arthritis, such as prednisone a corticosteroid and Plaquenil hydroxychloroquine, can actually trigger eye problems. “Plaquenil, on rare. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage.