Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Malaria chloroquine prophylaxis Hydroxychloroquine skin peeling Chloroquine diphosphate salt sigma solubility For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Rates of plaquenil toxicity The Risk of Retinal Toxicity with Plaquenil - Sjogren's, Plaquenil Toxicity - Symptoms, Treatment, Risk Factors. Chloroquine ineffective in exoerythrocyticDoes hydroxychloroquine cause diarrheaHydroxychloroquine eliminationPlaquenil and shingles vaccine Aug 29, 2014 Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. The Risk of Retinal Toxicity with Plaquenil. Plaquenil Uses, Dosage & Side Effects -. Recommendations on Screening for Chloroquine and.. Factors for toxicity related to hydroxychloroquine use. BACKGROUND 1 Hydroxychloroquine HCQ, brand name Plaquenil is commonly used for the long-term 2 management of a variety of chronic rheumatic diseases including systemic lupus erythematosus 3 and rheumatoid arthritis. A range of potential toxicities related to HCQ use have been reported Rates and Predictors of Hydroxychloroquine Retinal Toxicity in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus FREDERICK WOLFE1 AND MICHAEL F. MARMOR2 Objective. Hydroxychloroquine HCQ retinopathy is of concern because of the potential seriousness of visual loss and the medicolegal consequences of failure to detect toxicity. Once thought to be safe at a daily dose of 6.5mg/kg/day 16, newer studies show that many years of hydroxychloroquine treatment at a "safe dose" can still lead to toxicity 6. Newer guidelines state that daily dose 5mg/kg of real weight/day can lead to toxicity.