Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Plaquenil 200 mg uso Plaquenil help lower back pain Hydroxychloroquine 200 mg bid Pharmacokinetics of chloroquine phosphate A second type of scleroderma is called diffuse scleroderma. This means that more areas of the skin are involved and thickened, but there is a high degree of variability among patients. Skin of the arms, legs, and trunk are more likely to be involved. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Scleroderma is a multisystem disease with variable expression; thus any treatment plan must be holistic yet at the same time focus on the dominant organ disease. The goal of therapy is both to improve quality of life by minimizing specific organ involvement and subsequent life-threatening disease. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil forlimited sclera derma Scleroderma, Lupus and Scleroderma - Scleroderma News How effective is plaquenil for lupusChloroquine one drug treatmentWhat does a rash from plaquenil look likeDeschloroquine used on chloroquine resistant parasitesHydroxychloroquine anesthesia The following is an excerpt from chapter 23 of Systemic Sclerosis, 2nd Edition written by Dr. Laura Hummers and Dr. Fred Wigley. Download the full chapter at the bottom of this page. Because no two cases of Scleroderma are alike, identifying your disease subtype, stage, and involved organs is very important in determining the best course of action for treatment. Scleroderma Treatment Options Johns Hopkins Scleroderma.. My Approach to the Treatment of Scleroderma. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums. Being tested for possible lupus or scleroderma. If that doesn’t bring me out of the flare, we will start talking Imuran in addition to Plaquenil. When I asked him if I should stay home from work and pull my kids out of school, he said it may be an overreaction, but since we don’t really know, my health comes first. Sources of Pain in Scleroderma. Pain, along with fatigue, is one of the main symptoms of scleroderma and one of the toughest to deal with on a day–to–day basis. Scleroderma News, 05/11/2017. Sleep disturbances in systemic sclerosis SSc evidence for the role of gastrointestinal symptoms, pain and pruritus. Currently, there is no cure for scleroderma. Instead, treatment is directed at controlling and managing the symptoms. Because scleroderma can have many symptoms, a combination of approaches is often needed to treat and manage the disease effectively. Skin treatments For localized scleroderma, topical medications often are beneficial. Moisturizers are used to prevent the skin from drying out, as well as to treat hardened skin.