Hydroxychloroquine cardiotoxicity

Discussion in 'Canadian Drugs' started by malyr, 20-Mar-2020.

  1. conkord58 Well-Known Member

    Hydroxychloroquine cardiotoxicity

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    A man in his 60s presented to our clinic for worsening exercise capacity, dyspnoea on exertion for 18 months and chest pain not associated with exercise. He had medical history of rheumatoid arthritis RA, Sjogren’s syndrome, Raynaud’s phenomenon, gastro-oesophageal reflux, dyslipidaemia and Parkinson’s disease. He was on hydroxychloroquine HCQ for RA at the time of presentation. A. Cardiotoxicity from various medical therapies remains an important cause of heart disease and includes coronary artery disease, valvular heart disease, arrhythmias, and drug‐induced cardiomyopathy. 1, 2 Given the low cost, widespread availability and clinical efficacy, chloroquine CQ and hydroxychloroquine HCQ are commonly used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, and other connective tissue disorders. If cardiotoxicity is suspected, prompt discontinuation of hydroxychloroquine sulfate may prevent life-threatening complications. Hydroxychloroquine sulfate prolongs the QT interval. Ventricular arrhythmias and torsades de pointes have been reported in patients taking hydroxychloroquine sulfate see OVERDOSAGE.

    However, the exact mechanism of HCQ cardiotoxicity remains unclear and it is difficult to identify risk factors. Abstract: Hydroxychloroquine (HCQ)-induced cardiomyopathy is one of the rare but severe complications following prolonged HCQ use.

    Hydroxychloroquine cardiotoxicity

    DailyMed - HYDROXYCHLOROQUINE SULFATE tablet, Chloroquine‐induced cardiomyopathy a reversible cause of.

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  7. The diagnosis of hydroxychloroquine-induced cardiotoxicity, although rare, should be considered for patients, such as the one described, who have a history of hydroxychloroquine use, a quiescent underlying autoimmune connective tissue disease, and unexplained chest symptoms, electrical or mechanical cardiac dysfunction, or cardiac imaging studies suggestive of cardiomyopathy.

    • Hydroxychloroquine-induced Cardiotoxicity in a 39-year-old..
    • Hydroxychloroquine Tablets - FDA prescribing information..

    Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. HCQ cardiotoxicity is uncommon, but as HCQ use and duration of therapy increase, we expect more cases to occur. Further study will be necessary to identify risk factors for this complication and to estimate the relative impact of antimalarial therapy on cardiac disease in SLE patients. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

  8. valio70 XenForo Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Hydroxychloroquine Oral Route Description and Brand. Stopping plaquenil. DailyStrength Withdrawal syndrome in Plaquenil how severe and when it.
  9. malatron XenForo Moderator

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    Chloroquine And Hydroxychloroquine Toxicity - StatPearls - NCBI Bookshelf
  10. xproject User

    Chloroquine West-ward Pharmaceutical Corp FDA Package. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine.

    Ghloroquine excretion in semen following antimalarial‐drug.