While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. The studies that do exist show mixed results (some show Nonetheless, despite the lack of clinical studies, rheumatologists feel that hydroxychloroquine may have a potential beneficial effect in helping patients with symptoms of fatigue and achiness, which are common complaints in patients with Sjögren’s. Plaquenil and neurotransmitter acetylcholine What is plaquenil Plaquenil sore throat Plaquenil Hydroxychloroquine sulfate is a drug originally used to prevent or treat malaria. Malaria is a serious but rare disease caused by bites from infected mosquitos. Now the drug is used to treat inflammatory diseases. This type of disease occurs when the body's immune system attacks its own healthy tissue. Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. How do you take Plaquenil? Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders. The good news is that hydroxychloroquine targets the immune system without causing an increase in the risk of infection or cancer that can be seen with other immunosuppressant medications. How the drug works is unclear, but recent research has pointed to an inhibitory effect on toll-like receptors that are proteins involved with inflammation. Plaquenil works for what diseases Plaquenil Hydroxychloroquine - Side Effects, Dosage., Lupus Medicines Hydroxychloroquine - Brigham and Women's. Plaquenil joint painPlaquenil autoimmune thyroiditisPlaquenil reviews side effectsDoes plaquenil cause heartburn May 24, 2018 Medications can include Corticosteroids. Drugs, such as prednisone, can help prevent your immune system from attacking. Antimalarial drugs. Hydroxychloroquine Plaquenil can treat mild mixed connective tissue disease. Calcium channel blockers. This category of medications, including. Mixed connective tissue disease - Diagnosis and treatment.. Inflammatory Osteoarthritis And Plaquenil. Hydroxychloroquine Plaquenil. To make sure Plaquenil is safe for you, tell your doctor if you have a history of vision changes or damage to your retina caused by an anti-malaria medication; heart disease, heart rhythm disorder such as long QT syndrome; diabetes; a stomach disorder; an allergy to quinine; liver or kidney. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Allergic and psoriasis-like rashes tend to develop within the first few weeks or months of starting Plaquenil. If Plaquenil helps a serious chronic disease such as lupus, it may be taken for years. Some of these long-term users will develop grayish-blue pigmentation on. Pigmentation associated with long-term use of Plaquenil. their shins and forearms.