One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. How to quit taking hydroxychloroquine Chloroquine resistant areas Plaquenil rosacea treatment Hydroxychloroquine for discoid lupus The estimated risk of hydroxychloroquine retinopathy in patients on chronic hydroxychloroquine therapy ranges from 0.4% to 8.0%. 1 Toxicity is thought to be dependent on cumulative total dose. 3 Additional factors that can precipitate early toxicity are concomitant renal disease and use of tamoxifen. 3. Hydroxychloroquine HCQ trade name, Plaquenil and chloroquine CQ trade name, Aralen are drugs established in the treatment of autoimmune disease and skin disorders, but are also emerging as a treatment option in oncology and paediatric inflammatory disorders. How to set up a Hydroxychloroquine Retinopathy Screening Service. Yusuf IH, Luqmani R, Sharma SM, Downes SM. Hydroxychloroquine retinopathy an emerging problem. Eye Lond. 2017;2–6. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Downes sm hydroxychloroquine retinopathy Hydroxychloroquine toxicity Eye News, Hydroxychloroquine retinopathy Eye Hydroxychloroquine side efectsChloroquine prophylaxis pregnancy Hydroxychloroquine HCQ has been used for therapy of rheumatologic disorders since the 1950s. Ocular toxicity associated with HCQ use was initially described in the 1960s 1, 2. The incidence of HCQ retinopathy is estimated at 1 % after consumption of HCQ for 5 years. It is marked by paracentral and central scotoma and decreased color vision. Expanded spectral domain-OCT findings in the early.. How to set up a Hydroxychloroquine Retinopathy Screening.. FRI0639 A NOVEL SCREENING METHOD FOR HYDROXYCHLOROQUINE.. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during Of our 31 patients with a diagnosis of blindness or toxic maculopathy, 11 had documented blindness, in all cases attributed to a cause other than HCQ-related ocular toxicity stroke 27%, pre-existing macular disease 18%, diabetic retinopathy 18%, hypertensive retinopathy 9% and cataracts 9%.