It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG). Symptoms and consequences include palpitations, dizziness, lightheadedness (during shorter episodes), fainting (during longer episodes), and sudden cardiac death. Torsades occurs as both an inherited (linked to at least 17 genes) Common causes for torsades de pointes include drug-induced QT prolongation and less often diarrhea, low serum magnesium, and low serum potassium or congenital long QT syndrome. Plaquenil for sickle cell anemia Information on plaquenil medication Wellbutrin and plaquenil Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Published December 2010. Publications Drug-induced QT prolongation and Torsades de Pointes - the facts. This article is more than five years old. Some content may no longer be current. Certain drugs and combinations of drugs resulting in drug interactions are common contributors to torsades de pointes risk. It can be seen in malnourished individuals and chronic alcoholics, due to a deficiency in potassium and/or magnesium. Chloroquine torsades Chloroquine Nivaquine, Resochin Healing Is Divine., Chloroquine Dosage Guide with Precautions - Plaquenil maculopathy photosPlaquenil alcohol interactionOct chloroquine toxicity5 years for plaquenil to leave eyeArthritis medicine plaquenil Hydroxychloroquine can be detected in the cord blood at delivery in concentrations similar to those in the maternal serum Costedoat-Chalumeau 2002. In animal reproduction studies with chloroquine, accumulation in fetal ocular tissues was observed and remained for several months following drug elimination from the rest of the body. Hydroxychloroquine Professional Patient Advice -. Drug-induced QT prolongation and Torsades de Pointes - the.. CredibleMeds® has reviewed available evidence for the drugs on the.. Quinine, chloroquine, artesunate-amodiaquine and dihydroartemisinin-piperaquine, have been associated with a low risk of cardiotoxicity. 2. Drug-induced QT/QTc interval prolongation is a surrogate indicator for increased risk of drug-induced torsade de pointes TdP, a potentially lethal polymorphic ventricular tachycardia. Cardiac arrhythmias, conduction disorders such as bundle branch block / atrio-ventricular block, QT interval prolongation, torsade de pointes, ventricular tachycardia and ventricular fibrillation have been reported with therapeutic doses of Chloroquine as well as with overdose. The risk is greater if Chloroquine is administered at high doses. Primaquine is a medication used to treat and prevent malaria and to treat Pneumocystis pneumonia. Specifically it is used for malaria due to Plasmodium vivax and Plasmodium ovale along with other medications and for prevention if other options cannot be used. It is an alternative treatment for Pneumocystis pneumonia together with clindamycin. It is taken by mouth.