At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. Chloroquine protein degradation Plaquenil for ms Weight loss taking hydroxychloroquine Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. Children's doses are based on body weight and are calculated as 5 mg of hydroxychloroquine base per kilogram of body weight to a maximum dose of 400 mg. For treatment of acute attacks of malaria, the recommended starting dose for adults is 800 mg followed by 400 mg after 6 to 8 hours. The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Plaquenil and weight gain Plaquenil and weight gain? - Sjogren's World, Plaquenil - Uses, Side Effects, Interactions - Does going off plaquenil cause fever after surgery Hi everyone. I know this seems shallow and there are more important things in life like getting healthy but I have a question for those who are taking or have taken Medrol and or Plaquenil. Has anyone experienced weight gain? I have been reading up on side effects and weight gain and swollen face. Medrol, Plaquenil and weight gain - Sclero Forums MAIN.. Plaquenil & Weight Gain/Loss -. Hydroxychloroquine Reviews Everyday Health. Plaquenil and Weight gain. I was just wondering if anyone else has experienced this. I started on Plaquenil almost a year ago when diagnosed with MCTD and have gained almost 20 pounds. The only other med I am on is levothyroxine, my thyroid is well controlled and I have been on this med over 3 years. Almost any med that can cause weight loss can also cause weight gain. I also find that eating a lot of carbohydrates helps with the GI effects of the plaq and that can contribute to weight gain. Plaquenil and Weight increased - from FDA reports Summary Weight increased is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Actemra, and have Pain.