Low-dose hydroxychloroquine in treatment of porphyria

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  1. lutckiy Well-Known Member

    Low-dose hydroxychloroquine in treatment of porphyria

    These disorders are usually inherited, meaning they are caused by abnormalities in genes passed from parents to children. When a person has a porphyria, cells fail to change body chemicals called porphyrins and porphyrin precursors into heme, the substance that gives blood its red color.

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    There were no significant side effects of either treatment. CONCLUSIONS Hydroxychloroquine, 100 mg twice weekly, is as effective and safe as phlebotomy in patients with PCT, although noninferiority was not established. Given these results, higher-dose regimens of hydroxychloroquine, which have more side effects, do not seem justified. Cumulative probability of time to remission of 17 patients with porphyria cutanea tarda randomized to treatment by phlebotomy n=7, black line or low-dose hydroxychloroquine n=10, gray line. The median time to remission was similar with hydroxychloroquine. Dosing recommendations in porphyria cutanea tarda. In the treatment of porphyria cutanea tarda, hydroxychloroquine 100 mg should be prescribed twice weekly for one month, then 200 mg/day until plasma porphyrin levels are normal for at least a month.

    Bone marrow is the soft, spongelike tissue inside the bones; it makes stem cells that develop into one of the three types of blood cells—red blood cells, white blood cells, and platelets. The body makes heme mainly in the bone marrow and liver.

    Low-dose hydroxychloroquine in treatment of porphyria

    Porphyria Types, Symptoms, Causes, and Treatment, Low-Dose Hydroxychloroquine is as Effective as Phlebotomy in Treatment.

  2. Effects of hydroxychloroquine on taste
  3. Porphyria cutanea tarda PCT is an iron-related disorder that responds to treatment by phlebotomy or low-dose hydroxychloroquine, but comparative data on these treatments are limited. The hypothesis is that hydroxychloroquine is noninferior to phlebotomy in terms of time to remission.

    • Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda..
    • Hydroxychloroquine DermNet NZ.
    • Hydroxychloroquine Sulfate Monograph for Professionals..

    Dec 20, 2019 Porphyria cutanea tarda PCT is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase UROD is deficient. Approximately 80% of all cases of porphyria cutanea tarda are acquired; 20% are familial, although the ratio may vary among different geographic regi. Methods. We analyzed data from 48 consecutive patients with well-documented PCT to characterize susceptibility factors; patients were treated with phlebotomy 450 mL, every 2 weeks until they had serum ferritin levels of 20 ng/mL or low-dose hydroxychloroquine 100 mg orally, twice weekly, until at least 1 month after they had normal plasma levels of porphyrin. Low-dose oral chloroquine in the treatment of porphyria cutanea tarda. Ashton RE, Hawk JL, Magnus IA. Seven patients with porphyria cutanea tarda received a total of ten courses of low-dose oral chloroquine therapy 125 mg chloroquine phosphate twice weekly.

  4. ozoned Well-Known Member

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  5. ActiveAir Guest

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hydroxychloroquine DermNet NZ Hydroxychloroquine Sulfate Photosensitivity Reaction Reports. Will you have Photosensitivity reaction with Plaquenil.
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    Management of autoimmune neutropenia in Felty's syndrome and systemic. Autoimmune neutropenia, caused by neutrophil-specific autoantibodies is a common phenomenon in autoimmune disorders such as Felty's syndrome and systemic lupus erythematosus. Felty's syndrome is associated with neutropenia and splenomegaly in seropositive rheumatoid arthritis which can be severe and with recurrent bacterial infections.

    Drug-Induced Neutropenia
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